Figure 7. Loss of p47phox improves adriamycin-induced macrophage infiltration.
(A) F4/80 staining in kidneys from uninjured (Control) or adriamycin-treated (1w-ADR and 4w-ADR) WT, α1KO, p47phoxKO, and DKO mice. Slides were counterstained with toluidine blue (blue staining). (B) The number of macrophages (arrowhead) was evaluated in 20 randomly chosen field per kidney. The values represent the mean ± SD of the kidneys indicated. (*) and (δ) are as in Fig. 1. Note the increased number of macrophages in 4 week injured integrin α1KO mice which was reduced in kidneys of p47phoxKO and DKO mice.