Skip to main content
. Author manuscript; available in PMC: 2016 May 6.
Published in final edited form as: Neuron. 2015 Apr 23;86(3):768–782. doi: 10.1016/j.neuron.2015.03.040

Figure 5. Synaptic dynamics can account for frequency-dependent switching in CT-triggered modulation of VPm excitability.

Figure 5

(A) Same recording configuration as described in Figure 4E.

(B) Different example cell but the same excitability experiment as described in Figure 4F. Left, overlay of 10 sweeps in which dynamic-clamp was used to model the three standard CT-evoked conductances. Right, population PSTHs (5 ms bins) plotting difference in spike rates (i.e., trials with CT conductances versus control trials) for the first and tenth CT stimuli (n = 14 cells from 6 mice).

(C) Similar excitability experiment for the cell shown in B, but short-term facilitation of the excitatory conductances (g-AMPA and g-NMDA) was removed by statically repeating the first conductances across the train (n = 6 cells from 4 mice).

(D) Similar excitability experiment for the cell shown in B, but short-term depression of the inhibitory conductance (g-GABA) was removed, again by repeating the first conductance across the train (n = 7 cells from 4 mice). Data are represented as mean ± SEM.