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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pharm Res. 2014 Dec 6;32(6):1894–1906. doi: 10.1007/s11095-014-1583-0

Table 4.

Effect of AR-C155858 treatment on GHB blood-brain partitioning

Cplasma (mg/ml) Cbrain (mg/g) GHB
brain/plasma ratio
GHB alone 0.87 ± 0.05 0.22 ± 0.03 0.25 ± 0.02
GHB + AR-C155858 0.30 ± 0.03* 0.03 ± 0.01* 0.10 ± 0.03*

Cbrain, brain GHB concentration at steady-state; Cplasma, plasma GHB concentration at steady-state.

GHB 400 mg/kg i.v. bolus + 208 mg/kg/h i.v. infusion was administered alone or with AR-C155858 (5 mg/kg i.v. bolus). AR-C155858 was administered 5 minutes after GHB administration. Brain and plasma samples were obtained at 4 h. Student’s t-test was used to determine statistically significant differences. Data presented as mean ± SD, n=4–5.

*

P < 0.05 significantly different from GHB alone.