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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Pharm Res. 2014 Dec 17;32(6):2051–2059. doi: 10.1007/s11095-014-1598-6

Table I.

Endocytic inhibitors, endosomal buffering agents, and mechanisms

Drug Mechanism Highest non-toxic
concentration
Methyl-β-cyclo-dextrin Sequesters plasma membrane cholesterol, inhibiting lipid raft formation 12.5 mg/mL
Genistein Inhibits tyrosine kinase necessary for caveolar vesicle trafficking 62.5 µg/mL
Amantadine Stabilizes intracellular clathrin and prevents recycling to plasma membrane 6.25 µg/mL
Chlorpromazine Stabilizes intracellular clathrin and prevents recycling to plasma membrane 1.25 mM