TABLE II.
Univariate analysis of factors predictive of outcome.
| Factor | Surgeries (N) | 5- year LRFS probability (SE) | P | 5-year EFS probability (SE) | P | Patients (N) | 5-year OS probabilit y (SE) | P |
|---|---|---|---|---|---|---|---|---|
| Patient factors | ||||||||
| Age* | 181 | 0.901 (0.027) | 0. 7386 | 0.602 (0.063) | 0.696 | 173 | 0.739 (0.047) | 0.7394 |
| Gender | ||||||||
| Male | 94 | 0. 888 (0.039) | 0.5847 | 0.512 (0.103) | 0.0012 | 87 | 0. 680 (0.074) | 0. 0598 |
| Female | 87 | 0.912 (0.034) | 0.693 (0.071) | 86 | 0. 795 (0.053) | |||
| Race | ||||||||
| White | 125 | 0.899 (0.031) | 0.9964 | 0.613 (0.072) | 0.8438 | 120 | 0. 741 (0.054) | 0.8708 |
| African American | 45 | 0.903 (0.052) | 0.566 (0.130) | 42 | 0. 716 (0.095) | |||
| Other | 11 | 0.896 (0.110) | 0.589 (0.266) | 11 | 0. 794 (0.164) | |||
| History of previous cancer | ||||||||
| Absent | 169 | 0.913 (0.026) | 0.0299 | 0.630 (0.062) | 0.0004 | 162 | 0.752 (0.046) | 0.0162 |
| Present | 12 | 0.692 (0.216) | 0.212 (0.502) | 11 | 0.367 (0.504) | |||
| Disease factors | ||||||||
| Tumor site | ||||||||
| Lower extremity | 0.911 (0.027) | 0.1962 | 0.629 (0.064) | 0.0415 | 0.760 (0.047) | 0.0563 | ||
| Femur | 108 | 105 | ||||||
| Tibia | 39 | 37 | ||||||
| Fibula | 10 | 10 | ||||||
| Upper extremity | 0.824 (0.099) | 0.433 (0.219) | 0.584 (0.74) | |||||
| Humerus | 23 | 20 | ||||||
| Ulna | 1 | 1 | ||||||
| Distant metastases at diagnosis | ||||||||
| Absent | 135 | 0.946 (0.021) | 0.0005 | 0.684 (0.060) | <0.0001 | 132 | 0.823 (0.041) | <0.0001 |
| Present | 46 | 0.741 (0.099) | 0.363 (0.192) | 41 | 0.460 (0.169) | |||
| Pathologic fracture | ||||||||
| Absent | 175 | 0.898 (0.027) | 0.789 | 0.606 (0.064) | 0.3906 | 167 | 0.747 (0.047) | 0.0814 |
| Present | 6 | 0.999 (0.013) | 0.436 (0.480) | 6 | 0.438 (0.480) | |||
| Skip metastases | ||||||||
| Absent | 166 | 0.898 (0.028) | 0.819 | 0.606 (0.065) | 0.5736 | 158 | 0.756 (0.047) | 0.0664 |
| Present | 15 | 0.919 (0.085) | 0.535 (0.238) | 15 | 0.553 (0.226) | |||
| Ratio of axial length of tumor to bone* | 181 | 0.928(0.033) | 0.7891 | 0.603 (0.064) | 0.2895 | 173 | 0.742 (0.048) | 0.401 |
| Treatment factors | ||||||||
| Planned bony resection margin (cm) | ||||||||
| 1.5 | 39 | 0.832 (0.085) | 0.3657 | 0.498 (0.188) | 0.4379 | 36 | 0.763 (0.112) | 0.9354 |
| 3 | 81 | 0.926 (0.032) | 0.626 (0.085) | 76 | 0.740 (0.066) | |||
| 5 | 61 | 0.900 (0.043) | 0.613 (0.097) | 61 | 0.726 (0.074) | |||
| Actual bony resection margin (cm)* | 181 | 0.916(0.026) | 0.1429 | 0.601 (0.064) | 0.8629 | 173 | 0.740 (0.047) | 0.8622 |
| Bony resection margin | ||||||||
| Negative | 172 | 0.901 (0.027) | 0.804 | 0.613 (0.063) | 0.1345 | 164 | 0.749 (0.047) | 0.1353 |
| Positive | 9 | 0.874 (0.135) | 0.396 (0.381) | 9 | 0.558 (0.265) | |||
| Soft tissue resection margin | ||||||||
| Negative | 176 | 0.897 (0.028) | 0.7705 | 0.604 (0.064) | 0.6161 | 169 | 0.743 (0.048) | 0.4477 |
| Positive | 5 | 0.999 (0.012) | 0.508 (0.392) | 4 | 0.597 (0.365) | |||
| Tumor necrosis (Rosen grade) | ||||||||
| ≤90% | 0.875 (0.042) | 0.2761 | 0.484 (0.108) | 0.0007 | 0.673 (0.075) | 0.0337 | ||
| 1 | 48 | 45 | ||||||
| 2 | 46 | 43 | ||||||
| >90% | 0.924 (0.031) | 0.727 (0.065) | 0.804 (0.051) | |||||
| 3 | 70 | 69 | ||||||
| 4 | 17 | 17 | ||||||
| Treatment plan | ||||||||
| On protocol | 118 | 0.918 (0.029) | 0.2805 | 0.614 (0.075) | 0.5939 | 114 | 0.743 (0.056) | 0.8422 |
| Non-protocol treatment plan | 63 | 0.866 (0.052) | 0.575 (0.109) | 59 | 0.792(0.078) | |||
| Year of treatment* | 181 | 0.900(0.027) | 0.7460 | 0.593 (0.067) | 0.0872 | 173 | 0.743 (0.049) | 0.4619 |
*
Analyzed as continuous variables.
P-values in bold are significant at α=.10.
LRFS, local recurrence-free survival; EFS, event-free survival; OS, overall survival; SE, standard error.