Table 2. Odds Ratio for Three Genetic Models for SNPs: rs5219 and rs757110.
Gene (SNP) | Control (total = 414) | T2DM (total = 1384) | OR (95% CI) co-dominant model, p-value, AIC | OR (95% CI) additive model, p-value, AIC | OR (95% CI) dominant model, p-value, AIC | OR (95% CI) recessive model, p-value, AIC |
KCNJ11 (rs5219) | CC/CT/TT 158/204/52HWE = 0.29 RAF = 0.37 | CC/CT/TT 535/656/193HWE = 0.77 RAF = 0.38 | СС: referenceCT: 0.95 [0.75–1.20] p = 0.67TT: 1.10 [0.77–1.56] p = 0.61AIC = 1945.6 | 1.02 [0.87–1.20] p = 0.81AIC = 1944.3 | 0.98 [0.78–1.23] p = 0.86AIC = 1944.3 | 1.13 [0.81–1.57] p = 0.47AIC = 1943.8 |
ABCC8 (rs757110) | TT/TG/GG 160/189/65HWE = 0.47RAF = 0.39 | TT/TG/GG 526/651/207HWE = 0.82RAF = 0.38 | TT: referenceTG: 1.08 [0.78–1.49] p = 0.63 GG: 1.03 [0.74–1.44] p = 0.85AIC = 1946.1 | 1.00 [0.85–1.17] p = 0.98AIC = 1944.3 | 1.03 [0.82–1.29] p = 0.81AIC = 1944.3 | 0.94 [0.75–1.18] p = 0.71AIC = 1944.2 |
AIC—Akaike Information Criterion, lower the AIC value better the model.Abbreviations: HWE—p-value of Hardy-Weinberg equilibrium, RAF—risk allele freaquency (T for KCNJ11(rs5219) and G for ABCC8 (rs757110)).