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. 2015 May 8;10(5):e0124662. doi: 10.1371/journal.pone.0124662

Table 2. Odds Ratio for Three Genetic Models for SNPs: rs5219 and rs757110.

Gene (SNP) Control (total = 414) T2DM (total = 1384) OR (95% CI) co-dominant model, p-value, AIC OR (95% CI) additive model, p-value, AIC OR (95% CI) dominant model, p-value, AIC OR (95% CI) recessive model, p-value, AIC
KCNJ11 (rs5219) CC/CT/TT 158/204/52HWE = 0.29 RAF = 0.37 CC/CT/TT 535/656/193HWE = 0.77 RAF = 0.38 СС: referenceCT: 0.95 [0.75–1.20] p = 0.67TT: 1.10 [0.77–1.56] p = 0.61AIC = 1945.6 1.02 [0.87–1.20] p = 0.81AIC = 1944.3 0.98 [0.78–1.23] p = 0.86AIC = 1944.3 1.13 [0.81–1.57] p = 0.47AIC = 1943.8
ABCC8 (rs757110) TT/TG/GG 160/189/65HWE = 0.47RAF = 0.39 TT/TG/GG 526/651/207HWE = 0.82RAF = 0.38 TT: referenceTG: 1.08 [0.78–1.49] p = 0.63 GG: 1.03 [0.74–1.44] p = 0.85AIC = 1946.1 1.00 [0.85–1.17] p = 0.98AIC = 1944.3 1.03 [0.82–1.29] p = 0.81AIC = 1944.3 0.94 [0.75–1.18] p = 0.71AIC = 1944.2

AIC—Akaike Information Criterion, lower the AIC value better the model.Abbreviations: HWE—p-value of Hardy-Weinberg equilibrium, RAF—risk allele freaquency (T for KCNJ11(rs5219) and G for ABCC8 (rs757110)).