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. 2015 May 8;10(5):e0126013. doi: 10.1371/journal.pone.0126013

Fig 3. Therapeutic effect of RNPN on cognitive dysfunction.

Fig 3

(A) The latency periods of saline-treated SAMR1 mice (open circle), saline-treated SAMP8 mice (open square), blank micelles-treated SAMP8 mice (closed triangle), TEMPOL-treated SAMP8 mice (closed circle), and RNPN-treated SAMP8 mice (closed square) were measured by the Morris water-maze test. The values are expressed as mean ± SEM values (n = 10). #P < 0.05, ##P < 0.01, compared with SAMR1 mice. *P < 0.05, **P < 0.01, compared with SAMP8 control mice. (B) The exploration times of saline-treated SAMR1 mice (open circle), saline-treated SAMP8 mice (open square), blank micelles-treated SAMP8 mice (closed triangle), TEMPOL-treated SAMP8 mice (closed circle), and RNPN-treated SAMP8 mice (closed square) were measured by the object-recognition test. The values are expressed as mean ± SEM values (n = 10). #P < 0.05, ##P < 0.01, compared with SAMR1 mice. *P < 0.05, **P < 0.01, compared with SAMP8 control mice.