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. 2015 May 8;10(5):e0126013. doi: 10.1371/journal.pone.0126013

Fig 5. Measurement of adverse effects.

Fig 5

(A) Effects of RNPN on blood pressure of SAMP8 mice in tail-cuff blood pressure method. Blood pressures before administration (white bar), after single administration (black bar), one week after starting treatment (red bar), two weeks after starting treatment (green bar), three weeks after starting treatment (yellow bar), and four weeks after starting treatment (blue bar) are shown. Values are expressed as mean ± SEM (n = 10). *P < 0.05 compared with SAMP8 control mice. (B) Effects of redox polymer nanotherapeutics on AST (white bar) and ALT (black bar) levels of SAMP8 mice. Values are expressed as mean ± SEM (n = 10). #P < 0.05, ##P < 0.01 compared with SAMR1 mice. *P < 0.05 compared with SAMP8 control mice.