Table 1. The levels of MDA, protein carbonyl, 8-OHdG, NO, superoxide scavenging activity (% inhibition of superoxide anion), antioxidant enzyme activity of SOD, catalase and GPx in the cortex area of SAMP8 mice.

Animal	SAMR1 mice	SAMP8 mice
Administered drug	Saline	Saline	Blank micelles	RNPN	TEMPOL
MDA (μM/μg protein)	0.037 ± 0.06	0.114 ± 0.029 ##	0.106 ± 0.041 ##	0.040 ± 0.020**	0.075 ± 0.025*
protein carbonyl (nM/mg protein)	0.718 ± 0.090	1.483 ± 0.275 ##	1.648 ± 0.256 ##	0.820 ± 0.111**	1.122 ± 0.321*
8-OHdG (nM/mg protein)	6.950 ± 1.614	15.441 ± 2.567 ##	14.270 ± 1.985 ##	11.284 ± 3.775**	10.856 ± 1.366**
SOD (units/mg protein)	1.025 ± 0.119	0.134 ± 0.027 ##	0.113 ± 0.04 ##	0.852 ± 0.04**	0.335 ± 0.06*
CAT (units/mg protein)	7.583 ± 0.960	6.325 ± 0.823 #	5.695 ± 0.536 #	6.115 ± 0.378	7.116 ± 1.659*
GPx (units/mg protein)	18.754 ± 1.904	14.755 ± 1.392 #	13.924 ± 1.730 #	14.177 ± 1.275	11.720 ± 0.747
NO (μM/g tissue)	18.387 ± 3.754	47.081 ± 5.551 ##	45.121 ± 3.483 ##	30.664 ± 9.534**	39.571 ± 4.613*
superoxide anion (% inhibition/mg tissue)	63.878 ± 4.61	17.827 ± 6.427 ##	15.326 ± 4.896 ##	54.021 ± 6.751**	37.133 ± 8.532**

(n = 5)

^#P < 0.05

^##P < 0.01, compared with SAMR1 mice

*P < 0.05

**P < 0.01, compared with SAMP8 control mice