Table 2. The levels of MDA, protein carbonyl, 8-OHdG, NO, superoxide scavenging activity (% inhibition of superoxide anion), antioxidant enzyme activity of SOD, catalase and GPx in the hippocampus area of SAMP8 mice.
| Animal | SAMR1 mice | SAMP8 mice | |||
|---|---|---|---|---|---|
| Administered drug | Saline | Saline | Blank micelles | RNPN | TEMPOL |
| MDA (μM/μg protein) | 0.034 ± 0.002 | 0.082 ± 0.011 ## | 0.074 ± 0.008 ## | 0.036 ± 0.002** | 0.053 ± 0.010** |
| protein carbonyl (nM/mg protein) | 0.771 ± 0.100 | 1.166 ± 0.339 ## | 1.078 ± 0.130 ## | 1.007 ± 0.092** | 0.867 ± 0.093 |
| 8-OHdG (nM/mg protein) | 10.081 ± 2.993 | 23.421 ± 3.236 ## | 24.778 ± 4.193 ## | 12.940 ± 2.254** | 14.824 ± 1.267** |
| SOD (units/mg protein) | 1.644 ± 0.343 | 0.642 ± 0.099 ## | 0.325 ± 0.063 ## | 1.445 ± 0.284** | 0.830 ± 0.155* |
| CAT (units/mg protein) | 7.682 ± 1.162 | 7.985 ± 0.233 | 7.116 ± 0.690 | 7.851 ± 0.428 | 7.107 ± 0.596 |
| GPx (units/mg protein) | 21.108 ± 3.297 | 16.265 ± 2.186 # | 14.614 ± 2.310 # | 15.950 ± 2.159 | 15.719 ± 1.060 |
| NO (μM/g tissue) | 21.858 ± 5.692 | 48.263 ± 4.385 ## | 46.384 ± 3.023 ## | 35.230 ± 3.047** | 40.873 ± 7.587* |
| superoxide anion (% inhibition/mg tissue) | 63.229 ± 4.468 | 19.075 ± 2.989 ## | 21.712 ± 12.526 ## | 46.662 ± 5.869** | 36.900 ± 9.592** |
(n = 5)
#P < 0.05
##P < 0.01, compared with SAMR1 mice
*P < 0.05
**P < 0.01, compared with SAMP8 control mice