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. 2015 May 8;10(5):e0126015. doi: 10.1371/journal.pone.0126015

Fig 2. Nuclear MRTF-A expression is more prominent in SSc skin then healthy control.

Fig 2

A. Representative pictures of healthy control and SSc sections of biopsy. Histological samples of human skin were stained with MRTF-A antibody (1:2000). Higher magnification of epithelium and small vessels (20X) in papillary dermis. Brown arrows = MRTF-A nuclei, Blue arrow = hematoxylin stained nuclei without MRTF-A. Graphical representations of % nuclei in epidermis, vasculature, and interstitial cells in papillary dermis. Histological samples of 5 healthy control and 9 scleroderma human skin were evaluated for nuclear staining. B. Total cells with MRTF-A nuclear localization in the epidermis, vasculature, and interstitial papillary dermal layers were counted and compared with the total amount of nuclei in the epidermal/papillary dermal layer. White bars = healthy controls, Black bars = SSc (* = p<0.01 using nonparametric Mann-Whitney U, two-tailed).