Fig 3. Increased expression of MRTF-A in the SSc epidermis and at the epidermal dermal junction in established SSc correlates with increased intracellular procollagen, and SMA.

The expression of MRTF-A, procollagen type I, and SMA was detected by immunohistochemical staining in the epidermis and papillary dermis of early and established SSc patients and controls healthy control patients. Arrows point to staining in vascular cells (V), epidermis (e), and fibroblast (F).