Table 2. Positive rate of autoantibodies observed in CSF validation cohort with focused autoantigen microarrays.
| Autoantigen | Positive rate of corresponding autoantibodies | P value a | ||||
|---|---|---|---|---|---|---|
| Control b | Non-NPSLE c | NPSLE d | Non-NPSLE cf. control | NPSLE cf.control | Non-NPSLE cf. NPSLE | |
| RPLP2 | 0.00% | 25.00% | 33.33% | 0.0004 | <0.0001 | 0.4505 |
| SS-A | 0.00% | 10.71% | 31.11% | 0.0414 | <0.0001 | 0.0450 |
| RPLP1 | 0.00% | 25.00% | 28.89% | 0.0004 | <0.0001 | 0.7172 |
| RPLP0 | 0.00% | 21.43% | 26.67% | 0.0014 | <0.0001 | 0.6136 |
| CHRND | 5.88% | 7.14% | 4.44% | 1 | 1 | 0.6350 |
| PCNA | 0.00% | 3.57% | 4.44% | 0.3544 | 0.2171 | 1 |
| EIF2C1 | 0.00% | 3.57% | 2.22% | 0.3544 | 0.4688 | 1 |
| SNRPB d | 0.00% | 0.00% | 2.22% | 1 | 0.4688 | 1 |
| SNRPB(c) d | 0.00% | 0.00% | 2.22% | 1 | 0.4688 | 1 |
| C9orf11 | 1.96% | 0.00% | 2.22% | 1 | 1. | 1 |
| ATRX | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| CENPM | 0.00% | 0.00% | 0.00% | 1 | 1. | 1 |
| CSRPS | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| SNRPD1 | 0.00% | 7.14% | 0.00% | 0.1227 | 1 | 0.1438 |
| VPS29 | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| MADIL1 | 0.00% | 0.00% | 0.00% | 1 | 1. | 1 |
| APTX | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| ID01 | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| C1orf212 | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
| RANGRF | 0.00% | 0.00% | 0.00% | 1 | 1 | 1 |
a Chi-squared test or Fisher’s exact test were used to compare the positive rates between 2 groups;
bn = 51;
cn = 28;
dn = 45, autoantigens were listed according to the positive rates at decreasing order;
eSNRPB had 2 copies in the same block to be used as a quality evaluation index.