Table 3.

Entire patient cohort risk factors for PI Removal, PI Replacement, PIRR, Non-PIRR and CRSI

	PI† Removal		PI Replacement		PIRR ††		Non-PIRR§		CRSI⌷
	UVA**	MVA†††	UVA	MVA	UVA	MVA	UVA	MVA	UVA	MVA
	HR§§ (p)	HR (p)	HR (p)	HR (p)	HR (p)	HR (p)	HR (p)	HR (p)	HR (p)	HR (p)
RT¶ Used	5.52 (0.006)	5.42 (0.003)	1.20 (0.62)	n/a	2.12 (0.009)	1.35 (0.42)	2.02 (0.066)	n/a	1.96 (0.007)	1.48 (0.23)
Surgical Complication before TE# /PI Exchange	3.89 (0.013)	2.28 (0.17)	0.95 (0.93)	n/a	1.61 (0.24)	n/a	0.36 (0.29)	n/a	1.26 (0.53)	n/a
Silicone vs. Saline Implant	1.21 (0.71)	n/a	2.25 (0.012)	2.80 (0.006)	1.93 (0.025)	1.65 (0.10)	2.07 (0.057)	n/a	2.08 (0.004)	2.23 (0.003)
Nipple Reconstruction Performed	0.48 (0.18)	n/a	2.1 (0.027)	2.61 (0.006)	1.49 (0.16)	n/a	3.64 (0.0016)	n/a	1.84 (0.012)	2.31 (0.001)
Age ≤45 Years vs. >45 Years	1.01 (0.61)	n/a	1.96 (0.021)	1.69 (0.11)	1.03 (0.015)	1.02 (0.16)	1.15 (0.74)	n/a	1.63 (0.041)	1.02 (0.18)
Chemotherapy Used	2.20 (0.22)	n/a	1.79 (0.13)	n/a	2.02 (0.018)	1.45 (0.29)	1.29 (0.74)	n/a	1.68 (0.037)	1.27 (0.42)
Stage III vs. 0/I/II	4.10 (0.25)	n/a	1.04 (0.95)	n/a	3.43 (0.033)	1.27 (0.59)	0.88 (0.86)	n/a	4.33 (0.032)	1.23 (0.61)

KEY:

^†= Permanent Implant,

^††= Permanent Implant Replacement or Removal,

^§= Complication Requiring Surgery other than Implant Replacement or Removal,

^⌷= Complication Requiring Surgical Intervention,

^¶= Radiation Therapy,

^#= Tissue Expander,

^**= Univariate Analysis,

^†††= Multivariate Analysis,

^§§= Hazard Ratio.

Significant findings are bolded and italicized.