Table 1.
Summary of kinetic/uptake data
| Antibody mass (mg) | 5 | 10 | 20 | 40 | 60 | 100 |
|---|---|---|---|---|---|---|
| WB residence time (h) | 70.0 ± 0.6 | 67.6 ± 1.2 | 75.1 ± 2.7 | 78.4 ± 4.1 | 94.8 ± 4.3 | 95.1 ± 3.9 |
| Serum residence time (h/l) | 2.9 ± 0.6 | 5.0 ± 0.8 | 10.1 ± 0.6 | 10.8 ± 0.6 | 15.6 ± 1.6 | 14.5 ± 0.3 |
| Liver residence time (h) | 31.9 ± 1.1 | 22.2 ± 1.1 | 14.9 ± 0.7 | 18.7 ± 1.3 | 14.0 ± 0.7 | 12.9 ± 0.6 |
| Lesion residence time (h) | 0.14 ± 0.01 | 0.22 ± 0.05 | 0.54 ± 0.13 | 0.44 ± 0.07 | 0.33 ± 0.08 | 0.51 ± 0.05 |
Values are mean parameter estimates for each administered mass of hu-J591. Quoted uncertainties are the standard error of the mean.