Table 3.
T-Cell Phenotype Survival Statistics
| T-Cell Subset, Phenotype, Event, Quartilea | Events, No. | Events/1000 Person-Years (95% CI) | Adjustedb HR (95%CI) | P Values |
|---|---|---|---|---|
| CD4 T cells | ||||
| CD38+HLA-DR+ | ||||
| Death | ||||
| 1st (1.47–4.76) | 3 | 11.0 (2.3–32.2) | Reference | .030 |
| 2nd (4.76–6.7) | 10 | 36.6 (17.5–67.2) | 2.85 (.78–10.38) | |
| 3rd (6.7–10.5) | 11 | 53.7 (26.8–96.2) | 4.20 (1.15–15.41) | |
| 4th (10.5–28.7) | 16 | 79.4 (45.4–128.9) | 5.85 (1.68–20.32) | |
| AIDS | ||||
| 1st (1.47–4.76) | 10 | 39.9 (19.2–73.5) | Reference | .020 |
| 2nd (4.76–6.7) | 22 | 87.7 (54.9–132.7) | 2.03 (.96–4.31) | |
| 3rd (6.7–10.5) | 21 | 135.6 (83.9–207.2) | 3.39 (1.56–7.39) | |
| 4th (10.5–28.7) | 16 | 111.0 (63.4–180.2) | 2.58 (1.16–5.74) | |
| CD38+CD279+ | ||||
| Death | ||||
| 1st (1.49–5.61) | 6 | 22.4 (8.2–48.8) | Reference | .101 |
| 2nd (5.61–8.27) | 11 | 46.2 (23.1–82.7) | 2.06 (.76–5.58) | |
| 3rd (8.27–12.6) | 8 | 35.8 (15.5–70.6) | 1.27 (.43–3.77) | |
| 4th (12.6–56.1) | 15 | 67.2 (37.6–110.9) | 2.88 (1.11–7.44) | |
| AIDS | ||||
| 1st (1.49–5.61) | 12 | 47.4 (24.5–82.7) | Reference | .013 |
| 2nd (5.61–8.27) | 16 | 75.5 (43.2–122.6) | 1.65 (.77–3.50) | |
| 3rd (8.27–12.6) | 22 | 124.8 (78.2–189.0) | 2.89 (1.42–5.86) | |
| 4th (12.6–56.1) | 19 | 119.5 (72.0–186.7) | 2.66 (1.28–5.51) | |
| CD8 T cells | ||||
| CD38+HLA-DR+ | ||||
| Death | ||||
| 1st (14.2–39.3) | 4 | 14.9 (4.1–38.2) | Reference | .012 |
| 2nd (39.3–50.6) | 6 | 24.1 (8.9–52.5) | 1.62 (.46–5.75) | |
| 3rd (50.6–61.6) | 11 | 53.7 (26.8–96.1) | 3.24 (1.03–10.20) | |
| 4th (61.6–90.7) | 19 | 82.4 (49.6–128.7) | 4.82 (1.62–14.31) | |
| AIDS | ||||
| 1st (14.2–39.3) | 11 | 44.2 (22.1–79.2) | Reference | .062 |
| 2nd (39.3–50.6) | 23 | 106.1 (67.3–159.2) | 2.36 (1.14–4.86) | |
| 3rd (50.6–61.6) | 17 | 100.3 (58.4–160.6) | 2.23 (1.03–4.83) | |
| 4th (61.6–90.7) | 18 | 108.7 (64.4–171.9) | 2.66 (1.25–5.67) | |
| CD38+CD279+ | ||||
| Death | ||||
| 1st (4.39–18.7) | 7 | 28.3 (11.4–58.2) | Reference | .248 |
| 2nd (18.7–27.4) | 9 | 42.3 (19.3–80.2) | 1.33 (.48–3.68) | |
| 3rd (27.4–34.4) | 8 | 32.6 (14.1–64.2) | 0.90 (.33–2.51) | |
| 4th (34.4–84.6) | 16 | 65.1 (37.2–105.6) | 1.96 (.80–4.78) | |
| AIDS | ||||
| 1st (4.39–18.7) | 15 | 66.1 (37–109) | Reference | .598 |
| 2nd (18.7–27.4) | 12 | 71.6 (37–125.1) | 1.47 (.68–3.17) | |
| 3rd (27.4–34.4) | 26 | 125.2 (81.8–183.5) | 1.51 (.79–2.87) | |
| 4th (34.4–84.6) | 16 | 80.7 (46.1–131.0) | 1.19 (.58–2.41) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; HR, hazard ratio.
a Values in parentheses denote the percentage of the T-cell subset with the specified phenotype.
b Adjusted for set point HIV-1 load.