Table 4.
Univariate Analysis for Modeling
| Parameter | P Valuesa | HR (95% CI) |
|---|---|---|
| Univariate analysis results for AIDS | ||
| CD8 T cells | ||
| CD38+ (10% increment) | .0018 | 10.33 (10.12–10.54) |
| CD38+ (MFI) | <.0001 | 1.009 (1.005–1.013) |
| CD279+ (10% increment) | .5155 | 10.05 (9.89–10.22) |
| HLADR+ (10% increment) | .0655 | 10.16 (9.99–10.33) |
| CD38+HLA-DR+ (10% increment) | .0047 | 10.22 (10.07–10.38) |
| CD38+CD279+ (10% increment) | .1492 | 10.13 (9.95–10.32) |
| CD4 T cells | ||
| CD38+ (10% increment) | .0485 | 10.16 (10.00–10.33) |
| CD38+ (MFI) | .0007 | 1.009 (1.004–1.014) |
| CD279+ (10% increment) | .1660 | 10.13 (9.95–10.32) |
| HLADR+ (10% increment) | .0034 | 10.46 (10.15–10.79) |
| CD38+HLA-DR+ (10% increment) | .0012 | 10.65 (10.25–11.06) |
| CD38+CD279+ (10% increment) | .0170 | 10.30 (10.05–10.55) |
| Age at SC (10 year increment) | .5333 | 10.10 (9.79–10.42) |
| Set point VL (log10) | <.0001 | 2.062 (1.478–2.878) |
| Visit VL (log10) | <.0001 | 2.791 (1.944–4.008) |
| HIV-1 Subtype (AD) | .0222 | 2.916 (1.165–7.300) |
| HIV-1 Subtype (D) | .0342 | 2.362 (1.066–5.231) |
| Sex (female) | .4978 | 1.194 (0.715–1.992) |
| Univariate analysis results for death | ||
| CD8 T cells | ||
| CD38+ (10% increment) | .0049 | 10.42 (10.13–10.73) |
| CD38+ (MFI) | <.0001 | 1.01 (1.006–1.014) |
| CD279+ (10% increment) | .0369 | 10.18 (10.01–10.35) |
| HLADR+ (10% increment) | .0016 | 10.38 (10.14–10.62) |
| CD38+HLA-DR+ (10% increment) | .0003 | 10.38 (10.17–10.60) |
| CD38+CD279+ (10% increment) | .0043 | 10.28 (10.09–10.47) |
| CD4 T cells | ||
| CD38+ (10% increment) | .0685 | 10.2 (9.98–10.42) |
| CD38+ (MFI) | .003 | 1.009 (1.003–1.015) |
| CD279+ (10% increment) | .0933 | 10.16 (9.97–10.34) |
| HLADR+ (10% increment) | .0006 | 10.59 (10.25–10.93) |
| CD38+HLA-DR+ (10% increment) | .0001 | 10.85 (10.41–11.31) |
| CD38+CD279+ (10% increment) | .012 | 10.31 (10.07–10.55) |
| Age at SC (10 year increment) | .077 | 10.34 (9.96–10.74) |
| Set point VL (log10) | .0049 | 1.863 (1.208–2.871) |
| Visit VL (log10) | <.0001 | 3.117 (1.887–5.149) |
| HIV-1 Subtype (AD) | .032 | 4.058 (1.128–14.593) |
| HIV-1 Subtype (D) | .0866 | 2.854 (0.86–9.469) |
| Sex (female) | .2108 | 0.667 (0.354–1.258) |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; MFI, mean fluorescence intensity; SC, seroconversion; VL, HIV-1 viral load.
a By χ2 analysis.