FIGURE 2:

Histological effects of FGFR blockade on the hearts and kidneys of CKD animals. CKD was induced by 5/6 nephrectomy (Nx). Representative histological sections of the myocardium (upper panels) and kidneys (lower panels) from 5/6 nephrectomy rats treated for 3 weeks with vehicle (NaCl 0.9%) or PD173074 (1 mg/kg/day). Tissues show no evidence of mineralization by H&E or von Kossa staining, suggesting no adverse, toxic effects associated with the use of PD173074 at the dose used for up to 3 weeks. Magnification, ×20; scale bar: 100 µm. Interstitial fibrosis (arrows); tubular proteinaceous casts (asterisks).