. 2014 May 29;29(11):2028–2035. doi: 10.1093/ndt/gfu190

Table 1.

Renal and metabolic effects of 3 weeks of treatment with PD173074 or vehicle in 5/6 nephrectomy (Nx) rats

	Sham (reference values)	Sham + PD173074		5/6 Nx + Vehicle		5/6 Nx + PD173074		ANOVA
	Sham (reference values)	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	P-value
	(n = 8)	(n = 4)	(n = 4)	(n = 8)	(n = 8)	(n = 7)	(n = 7)	P-value
Body weight (g)	353 ± 13	196 ± 6^,^,^,***	335 ± 21	311 ± 13	378 ± 20	292 ± 20**	356 ± 19	<0.0001
Weight gain over 3 weeks (g)	163 ± 10		140 ± 15		67 ± 11*		76 ± 27*	0.0007
Serum creatinine (mg/dL)	0.19 ± 0.02	0.18 ± 0.01	0.21 ± 0.01	0.52 ± 0.04^,^,**	0.56 ± 0.04^,^,**	0.46 ± 0.06^,^,**	0.52 ± 0.05^,^,**	<0.0001
Blood urea nitrogen (mg/dL)	17 ± 0.1	14 ± 1.7	15 ± 0.7	37 ± 3.3^,^,**	35 ± 1.6^,^,**	41 ± 7.4^,^,**	33 ± 3.4^,^,**	<0.0001
Creatinine clearance (mL/min/100 g)	0.99 ± 0.07	0.90 ± 0.09	0.94 ± 0.06	0.40 ± 0.03^,^,**	0.40 ± 0.04^,^,**	0.46 ± 0.06^,^,**	0.45 ± 0.05^,^,**	<0.0001
Urine protein (mg/mg creatinine)	0.3 ± 0.03	0.3 ± 0.05	0.36 ± 0.02	5.8 ± 1.9	3.9 ± 1.4	5.4 ± 1.5	4.2 ± 1.6	0.0185
Systolic blood pressure (mmHg)	139 ± 2.5	137 ± 6.3	138 ± 4.1	213 ± 4.7^,^,**	215 ± 6.4^,^,**	203 ± 6.2^,^,**	203 ± 5.2^,^,**	<0.0001
Serum phosphate (mg/dL)	6.9 ± 0.3	6.4 ± 0.2	7.1 ± 0.6	6.1 ± 0.5	6.0 ± 0.3	5.9 ± 0.6	5.7 ± 0.5	0.3297
Serum FGF23 (pg/mL)	194 (179–225)	190 (171–208)	292 (230–351)	947 (676–1159)^,^,**	1315 (345–1900)^,^,**	548 (402–1111)^,^,**	865 (649–1434)^,^,**	<0.0001
PTH (pg/mL)	73 ± 18	nd	nd	177 ± 26	118 ± 40	127 ± 29	60 ± 39	0.0848
1,25(OH)₂D	143 ± 9	nd	nd	144 ± 10	125 ± 11	144 ± 9	131 ± 8	0.4932

Results are mean ± SEM or median (25–75th percentiles). Reference values: data from sham rats after 3 weeks of treatment with vehicle. Sham animals receiving NaCl pre-treatment: 2 weeks after 5/6 nephrectomy surgery; post-treatment: after 3 weeks of treatment with vehicle or PD173074; weight gain: difference (in g) between weight from pre- to post-treatment; FGF, fibroblast growth factor; PTH, parathyroid hormone; 1,25(OH)₂D, 1,25-dihydroxyvitamin D. nd, not determined.

*P < 0.001 in comparison with Sham.

**P < 0.05 in comparison with Sham + PD173074 pre-treatment.

***P < 0.05 in comparison with Sham + PD173074 post-treatment.

****P < 0.05 in comparison with 5/6 Nx + vehicle post-treatment.

*****P < 0.05 in comparison to 5/6 Nx + PD173074 post-treatment.