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. Author manuscript; available in PMC: 2015 May 9.
Published in final edited form as: JAMA. 2014 Jun 11;311(22):2305–2314. doi: 10.1001/jama.2014.6511

Figure 1. Discovery and Replication of the HNF1A p.E508K Variant.

Figure 1

Forest plot showing odds ratio estimates and 95% confidence intervals at p.E508K (squared boxes) from the 4 SIGMA studies, the SIGMA pooled mega-analysis, the replication studies, and the overall meta-analysis. Odds ratios for the meta-analyses are represented with a diamond. SIGMA mega-analysis represents the combined results from the 4 SIGMA studies. DMS indicates Diabetes in Mexico Study; MCDS, Mexico City Diabetes Study; MEC, Multiethnic Cohort; UIDS, Universidad Nacional Autónoma de México/Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Diabetes Study; T2D-GENES, Type 2 Diabetes Genetic Exploration by Next-Generation Sequencing in Multi-Ethnic Samples.

aRepresents data from the current article.