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. 2015 May 10;3:25. doi: 10.1186/s40478-015-0204-4

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© Hochgräfe et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Exploration behavior of MB-treated Tau^ΔK mice. Total activity (%) within 15 min is analyzed by an open field test after various MB treatment periods. (a) Preventive MB treatment for (a) 14.5mo and for (b) 6mo results in preservation of exploration behavior of Tau^ΔK mice similar to wild-type (WT) animals, whereas untreated Tau^ΔK mice show a significantly reduced activity. By contrast no group-differences are observed after therapeutic MB treatment for 3mo (c). Bars represent mean values ± SEM. Statistics: one-way analysis of variances with post-hoc Newman-Keuls multiple comparisons test. Asterisks indicate significant differences between groups; *: p < 0.05; **: p < 0.01; mo: months.