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. 2015 May 10;3:25. doi: 10.1186/s40478-015-0204-4

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© Hochgräfe et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histological analysis of conformationally changed and phosphorylated Tau in MB-treated mice. (a-e) MC1 immunoreactivity (epitope 5-15 + 312-322) indicates a pathological Tau conformation. MC1 positive neurons are prominent in somatosensory cortex (SSCx) of untreated Tau^ΔK mice with missorting of Tau to cell soma (arrows) and apical dendrites (arrowheads). In contrast MB treatment, especially preventive MB treatment for 14.5mo, clearly reduces MC1 immunoreactivity in Tau^ΔK mice. (f-j) Histological analysis of phosphorylated Tau using the AT180 antibody (dual phosphorylation epitope pThr231 + pSer235). Untreated Tau^ΔK mice display a massive mislocalization of phosphorylated Tau to cell soma (arrows) and apical dendrites (arrowheads) of SSCx neurons, whereas MB treatment diminishes the extent of AT180 phosphorylation. Scale bar: 50 μm.