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. 2015 Apr 22;15:21. doi: 10.1186/s12861-015-0070-0

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© Lochovska et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Physiological and pathological tooth formation in dissociated epithelia of mouse lower cheek region. (A) In samples with higher Spry2;Spry4 gene dosages (Spry2+/+;Spry4+/+, Spry2+/+;Spry4+/−, Spry2+/−; Spry4+/−, Spry2+/−; Spry4+/+), R2 Shh signaling domain (red arrow) merges with early M1 Shh signaling domain (yellow arrow) to form a typical elongated pEK (double yellow-red arrow) of the germ of M1. (B) In samples with lower Spry2;Spry4 gene dosages (Spry2+/+; Spry4−/−, Spry2+/−; Spry4−/−, Spry2−/−; Spry4+/+, Spry2−/−; Spry4+/−, Spry2−/−; Spry4−/−), R2 signaling domain (red arrow) persists in front of M1 signaling domain (yellow arrow) and became a signaling center of supernumerary tooth primordium (black arrow). Anterior direction is on the left side (the scale bar is 100 μm).