Table 1.
Motor performance after therapy with stem cells labeled by iron oxide nanoparticles in experimental designs of stroke
| Reference | Experimental model | SPION | Stem cell | Behavioral score | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Animal | Type | Type | Type | [Fe] μg/mL | Source | Type | Concentration | Route | Time | Sham | Lesion | |
| Wen et al. [33] (2014) | Rat (Sprague-Dawley) | MCDA | T (N/A) | In lab | 26 | Rat | NSC | 5 × 105 | Str | 2 d | N/A | N/A |
| Shichinohe et al. [17] (2013) | Rat (Wistar) | Lacunar | T (N/A) | Resovist | 1 | Rat | BMSC | 5 × 105 | Str | 7 d | N/A | N/A |
| Tarulli et al. [32] (2013) | Rat (Long Evans) | MCDA | P | MOC07F, Bang Lab. | 18,8 | Rat (femur and tibia) | BMSC | 3 × 106 | V | 3 d | N/A | N/A |
| Zhang et al. [16] (2013) | Mice (CD-1) | MCDA | T (5 mi) | In lab | 5-33 | Mice | NSC | 5 × 105 | IC; V | 1 d | N/A | N/A |
| Liu et al. [31] (2013) | Rat (Sprague-Dawley) | MCDA | T (5 mi) | In lab | N/A | Rat | NSC | 3 × 104 | Str | 2 d | N/A | N/A |
| Lu et al. [11] (2013) | Dog (Beagle) | MCDA | T (2 h) | In lab | N/A | Dog (bone marrow) | MSC | 3 × 106 | IC | 2 h | N/A | N/A |
| Kamiya et al. [30] (2013) | Rat (Sprague-Dawley) | MCDA | T (90 mi) | In lab | N/A | Rat (femur and tibia) | MSC | 107 (1 mL) | IC | 90 mi | N/A | N/A |
| Riegler et al. [13] (2012) | Rabbit (New Zealand) | OAF | T (5 mi) | FluidMag-D, FluidMag-lipid, FluidMag-DEAE, FluidMag, Endorem, Resovist | 16-56.0 | Rabbit | MSC | 105 (300 μL) | V | 5 mi | 2.9 ± 0.93 | 1.6 ± 0.38 |
| Detante et al. [29] (2012) | Rat (Sprague-Dawley) | MCDA | T (90 mi) | In lab | 10.0 | Human (bone marrow) | MSC | 105 (5 μL) | Str IC | 7 d | 3.3 ± 1.5 | 1.4 ± 0.8 |
| Yang et al. [28] (2011) | Rat (Sprague-Dawley) | MCDA | T (2 h) | In lab | 25 | Human (bone marrow) | MSC | 6 × 105 | IC | 14 d | N/A | N/A |
| Wang et al. [15] (2011) | Mice (CD-1) | MCDA | P; T (30 mi) | In lab | N/A | Mice (femur and tibia) | MSC | 5 × 105 (1 μL) | Str | 0 d | N/A | N/A |
| Gutiérrez-Fernández et al. [34] (2011) | Rat (Sprague-Dawley) | MCDA | P | Endorem | 11.2 | Rat (femur and tibia) | MSC | 2 × 106 (650 μL) | IC V | 0 d | 3.4 ± 0.89 | 1.7 ± 0.53 |
| Vandeputte et al. [21] (2011) | Rat (Fisher 344) | FOT1 | N/A | Resovist | 27.9 | Rat | rMAPC | 106 (1 μL) | Str | 1 d | N/A | N/A |
| Reddy et al. [12] (2010) | Rabbit (New Zealand) | ICAO | P | Resovist | 11.2 | Human (bone marrow) | MSC | 106 (1 μL) | IC | 4 d | N/A | N/A |
| PPA | ||||||||||||
| Crabbe et al. [20] (2010) | Mice | FOT1 | N/A | Resovist; Endorem; Sinerem | 11.2-27.9 | Mice | MSC | 104-5 × 106 | Str | 2 d | N/A | N/A |
| Rat (Fisher 344) | ||||||||||||
| Song et al. [27] (2009) | Rat (Sprague-Dawley) | MCDA | T (2 h) | Feridex | 11.2 | Human | NSC | 4 × 105 (1 μL) | Str | 1 d | 3.6 ± 2.1 | 2.3 ± 0.42 |
| Daadi et al. [26] (2009) | Rat (Sprague-Dawley) | MCDA | T (30 mi; 1 h) | Feridex | 11.2 | Human | ESC | 5 × 104-106 (1 μL) | Str | 2 d | 11.5 ± 7.2 | 32.4 ± 12.3 |
| Lee et al. [19] (2009) | Rat (Wistar) | FOT2 | N/A | MPIO | 11.2-27.9 | Human | MSC | 2 × 104 | IC | 2 d | N/A | N/A |
| Resovist | 2 × 106 | V | ||||||||||
| Walczak et al. [25] (2008) | Rat (Wistar) | MCDA | T (2 h) | Feridex | 11.2 | Rat (bone marrow) | MSC | 106 (2 μL) | V | 30 mi | N/A | N/A |
| Kim et al. [24] (2008) | Rat (Sprague-Dawley) | MCDA | T (2 h) | Feridex | 11.2 | Human | MSC | 105 | IC | 7d | N/A | N/A |
| Guzman et al. [23] (2008) | Rat (Sprague-Dawley) | MCDA | T (1 h) | Feridex | 11.2 | Mice | NSC | 2 × 105 (2 μL) | Str | −7 d | N/A | N/A |
| Rice et al. [14] (2007) | Mice (C57B/6) | MCDA | T (1 h) | Feridex | 11.2 | Mice | fMSC | 5 × 102 | IHp | 1 d | 3.7 ± 0.99 | 2.3 ± 0.48 |
| 5 × 103 | Str | |||||||||||
| Jendelová et al. [18] (2004) | Rat (Wistar) | FOT2 | N/A | Endorem | 11.2 | Rat | ESC | 2 × 105 | IC | 7 d | N/A | N/A |
| MSC | 2 × 106 | V | ||||||||||
| Hoehn et al. [22] (2002) | Rat (Wistar) | MCDA | T (1 h) | Sinerem | 20.0 | N/A | ESC | 2 × 3 × 104 | Str | 14 d | N/A | N/A |
| CC | ||||||||||||
BMSC, bone marrow-derived mesenchymal stromal cell; CC, corpus callosum; d, day; ESC, embryonic stem cell; fMSC, fat mesenchymal stem cell; FOT1, photothrombosis model (rose Bengal 20 mg/kg, 20 minutes, 540 nm light); FOT2, photothrombosis model (rose Bengal 10 mg/kg, 10 minutes, light 327 to 650 nm; h, hour; IC, intracortical; ICAO, occlusion of the internal carotid artery; IHp, intrahippocampal; MCDA, occlusion of the middle cerebral artery; mi, minute; MSC, mesenchymal stem cell; N/A, not identified; NSC, neural stem cell; OAF, femoral artery occlusion; P, permanent; PPA, ; rMAPC, rat multipotent adult progenitor cell; SPION, Superparamagnetic iron oxide nanoparticles; MCDA, occlusion of the middle cerebral artery; OAF, femoral artery occlusion; ICAO, Occlusion of the internal carotid artery; FOT1, photothrombosis model (rose Bengal 20 mg/ kg, 20min, 540nm light); FOT2, photothrombosis model (rose Bengal 10 mg/ kg, 10min, light 327 - 650nm; T, temporary; P, Permanent; mi, minute; h, hour; N/A, not identified; MOCO7F, MPIO, NSC, neural stem cell; BMSC, bone marrow-derived mesenchymal stroma cell; MSC, mesenchymal stem cells; rMAPC, rat multipotent adult progenitor cell; ESC, embrionary stem cell; Str, intrastriatum; V, endovascular; IC, intracortical; CC, Corpus callosum; IHp, intrahippocampal; fMSC, fat mesenchymal stem cell; d, days.