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. 2015 Apr 15;3(4):e12305. doi: 10.14814/phy2.12305

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Stimulation of uterine contractile activity with PGF_2α. (A) Representative recordings of stimulated uterine contractions in a YOUNG (top trace) and OLDER (bottom trace) rat dam by the accumulative addition of PGF_2α (range 0.1 nmol/L to 1 μmL/L, units shown are in log mol/L). (B) A dose–response curve to determine the effects of maternal age (YOUNG (n = 4) or OLDER (n = 7) on uterine integral activity to increasing doses of PGF_2α (range 0.1 nmol/L to 1 μmL/L, units shown are in log mol/L). Statistical analysis reveals that the dose–response curves were significantly different (P < 0.0005). LogEC₅₀ was significantly shifted by maternal age, YOUNG logEC₅₀= 0.009, OLDER logEC₅₀ =2.22.