Table 6.
Top 5 networks of DEG in laboring uterine horn between YOUNG and OLDER rat dams
| Network | Score | Focus molecules | Molecules in network |
|---|---|---|---|
| 1. Cell-To-Cell Signaling and Interaction, Cellular Movement, Immune Cell Trafficking | 40 | 21 | Akt, ALT, Bnip3, Ccl21, Cdkn1c, Ceacam11 (includes others), chemokine, CP, Cxcl3, Cxcl6, Cxcl11, Cxcl14, Fcer1, Foxo4, GC-GCR dimer, GOT, Granzyme, Gzmc (includes others), Gzmf, HLA-DQB1, IL12 (family), Il17r, Il1rn, Interferon alpha, Mttp, N-cor, Pi3k (family), Pik3ip1, Prf1, Prl4a1, Scgb1a1, Sema6d, Tlr, Tnf (family), Tnfrsf9 |
| 2. Endocrine System Development and Function, Small Molecule Biochemistry, Cardiovascular System Development and Function | 28 | 16 | Adcy, Adrb, Calcineurin protein(s), Cg, Cited1, Col15a1, Col8a1, Creb, Cyclin D, Cyp11a1, Dio2, E2f, Endothelin, ERK, Fam3d, Fsh, Fstl3, Gcgr, Gucy, Gucy1b3, Hsd17b2, Lh, Map2k1/2, Nppa, Nppb, Npr3, Oxt, Pkc(s), PLC, Pp2a, Proinsulin, Rap1, S100b, Slc6a2, TCF |
| 3. Cellular Movement, Cardiovascular System Development and Function, Organismal Development | 26 | 16 | Aoc1, Chi3 l1, collagen, Collagen Alpha1, Collagen type I, Collagen type II, Collagen type III, Collagen type IV, Collagen(s), elastase, ERK1/2, Fgf7, Fgf, Fibrin, Figf, Integrin, Kallikrein, Laminin, Lum, Mmp3, mmp12, Mmp, NfkB1-RelA, Nrg1, Nuclear factor 1, Olr1, Plau, Prl2c2 (includes others), Ptprz1, Rarres2, Serpina3n, Serpinb5, Serpine2, Stat1/3/5 dimer, trypsin |
| 4. Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response | 26 | 16 | A1cf, Actin, Afp, Anxa5, Apoh, AR, Ca2 + , Calcr, Clic5, Dbi, Dlgap1, Eppin-Wfdc6, Flvcr2, Fxdy3, Gpx3, Hnf4a, Htra3, Icam1, LPA, miR-30c-5p (and other miRNAs w/seed GUAAACA), Mtbp, Noxa1, OVOS/OVOS2, Pemt, Pfdn6, Ptp4a1, Rap2c, S100, Sec61b, Stambp, Tdo2, Tmem140, Tp53, Unc5b, Wfdc1 |
| 5. Lipid Metabolism, Small Molecule Biochemistry, Carbohydrate Metabolism | 26 | 15 | Adam8, Adam28, Adamts15, Ano7, Bag4, C14orf80, Capn13, Cd300e, Chst4, Far2, Gnrhr, Gpnmb, Gsdmd, Gsta4, Metalloprotease, Mfrp, miR-1976 (and other miRNAs w/seed CUCCUGC), miR-3173-5p (and other miRNAs w/seed GCCCUGC), miR-4640-5p (and other miRNAs w/seed GGGCCAG), Mlana, Ndufa3, Nnmt, Pcyt1a, Pla2 g15, Prss21, Psme2, RGD1562525 (includes others), Slc12a1, Slc4a11, Tnf, TRAPPC1, Trappc5, Trappc3 l, Ubc, Vars2 |