Table 2.
Transcription regulators and their respective target genes among the differentially expressed genes in liver tissue detected at 2.5 h from an LPS intra-mammary challenge at 7 days postpartum in Holstein cows. The fold-change response between LPS and control for each gene is reported in parenthesis.
| Transcription regulators | n | Target gene |
|---|---|---|
| MYC (1.81) | 24 | GADD45A (3.29), DDX3X (2.49), RHOB (2.44), PTGS2 (2.13), BCL2A1 (1.90), CEBPD (1.79), ZFP36 (1.79), KLF10 (1.70), FABP4 (1.69), GADD45B (1.63), GADD45G (1.62), MCL1 (1.61), XBP1 (1.57), HSP90AA1 (1.56), RRS1 (1.55), TOP1 (1.54), MMP7 (1.53), LIF (1.51), IL1A (1.50), AKAP8 (1.50), CAST (−1.51), GATA6 (−1.58), KAT2B (−1.71), SERPINF1 (−1.85) |
| CEBPD (1.79) | 6 | PTGS2 (2.13), BCL2A1 (1.90), MYC (1.81), FABP4 (1.69), MAP3K8 (1.65), LIF (1.51) |
| CREM (2.11) | 6 | RHOB (2.44), TIPARP (1.90), BHLHE40 (1.74), BTG2 (1.72), GADD45B (1.63), MCL1 (1.61) |
| XBP1 (1.57) | 6 | CXCL2 (2.02), MYC (1.81), PIK3R1 (1.80), TOP1 (1.54), LIF (1.51), PPIB (−1.57) |
| ZFP36 (1.79) | 5 | BIRC3 (2.89), PTGS2 (2.13), MYC (1.81), LIF (1.51), CNOT7 (−1.57) |
| GATA6 (−1.58) | 3 | MYC (1.81), LIF (1.51), APOB (−1.80) |
| KAT2B (−1.71) | 3 | PTGS2 (2.13), MYC (1.81), ACTN2 (1.54) |
| KLF10 (1.70) | 3 | MYC (1.81), LIF (1.51), SIAH1 (−1.56) |
| BHLHE40 (1.74) | 2 | CREM (2.11), NEDD9 (1.77) |
| BTG2 (1.72) | 2 | CREM (2.11), NEDD9 (1.77) |
| CNOT7 (−1.57) | 2 | BTG2 (1.72), ZFP36 (1.79) |
| ACTN2 (1.54) | 1 | KAT2B (−1.71) |