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. 2015 Apr 28;3(4):e12391. doi: 10.14814/phy2.12391

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Histogram of all cross-sectional areas of triceps muscles separated by fiber size in 200 μm² bins. (A) Representative individual WT, mdx, mdx:utrophin^+/− (het), and mdx:utrophin^−/− dko limb muscles at 3 months. The dko muscles were examined from a 2-month-old mouse. Note that the myofibers from the dystrophic mouse muscles tended to cluster at the smaller mean cross-sectional areas, although certainly very large myofibers were also present. (B) Representative individual WT, mdx, and mdx:utrophin^+/− (het) limb muscles at 6 months. Note that by 6 months the mdx profile had begun to resemble that of the WT mice, while the mdx:utrophin^+/− (het) limb muscles still retained more fibers with smaller cross-sectional areas. (C) Representative individual WT, mdx, and mdx:utrophin^+/− (het) limb muscles at 12 months. Note that even at 12 months, while the mdx myofiber areas completely overlapped those of the WT mouse, the mdx:utrophin^+/− (het) limb muscle fibers still remained clustered at the smaller cross-sectional areas.