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. 2015 Apr 28;3(4):e12391. doi: 10.14814/phy2.12391

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Dystrophin immunostaining in WT, mdx, mdx:utrophin^+/− (het), and dko triceps muscles. (A) All the myofibers in WT muscles express dystrophin at their sarcolemmas. (B) mdx muscle at 6 months showing a large cluster of revertant fibers. (C) mdx:utrophin^+/− (het) muscle at 6 months. Arrow points to a cytoplasmic extension of dystrophin. (D) mdx:utrophin^+/− (het) at 12 months. (E) mdx:utrophin^+/− (het) muscle at 16 months. (F) dko at 2 months. (G) Morphometric analysis of revertant fiber density as a percent of all myofibers. There were no significant differences between any of the dystrophic genotypes. Bar is 20 μm.