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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Cell Rep. 2015 Apr 23;11(5):808–820. doi: 10.1016/j.celrep.2015.04.004

Figure 7. Proposed model of protein recruitment to MLL-AF9.

Figure 7

A) One binding event of DOT1L to MLL-AF9 leads to H3K79 di-methylation, but binding of two (or three) sites on DOT1L to MLL-AF9 would significantly increase the residence time of DOT1L at a specific site on the chromatin. As the number of binding events of DOT1L to MLL-AF9 increase from one to two (or three), this increases the residence time of DOT1L at a specific site on the chromatin increasing the probability of proceeding to the H3K79 tri-methylated state. B) CBX8 is initially bound to MLL-AF9 leading to a default transcriptionally repressed state. Recruitment of activators such as DOT1L or AF4 leads to the displacement of CBX8 from MLL-AF9 leading to gene activation.