. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: DNA Repair (Amst). 2015 Feb 27;29:91–100. doi: 10.1016/j.dnarep.2015.02.016

Table 3.

Effect of dNTP pool biases on Pol κ error frequencies and specificity at mononucleotide microsatellites.

Template/ Correct dNTP	[dNTP], µM		Microsatellite Pol EF^a × 10⁻⁴ (N)	Microsatellite Errors
Template/ Correct dNTP	Correct	Other three	Microsatellite Pol EF^a × 10⁻⁴ (N)	Insertions	Deletions
[C]₁₀ /dGTP^b	250	20	200 (75)	2	15
[C]₁₀ /dGTP^b	20	20	63 (37)	1	24
[A]₈ / dTTP	20	250	100 (28)	3	8
[A]₈ / dTTP	250	250	100 (38)	4	5
[T]₈ / dATP^b	20	250	300 (41)	0	10

Calculated from the Observed HSV-tk mutant frequencies and the total number of independent mutational events shown in parentheses.

See Table 2 for unbiased [dNTP] conditions results.