Table 2.
Multivariate analysis of 6-month survival.
| BMT CTN 0302 | BMT CTN 0802 | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p | HR | 95% CI | p |
| Age > 40 years | 3.9 | 1.1 – 17.7 | 0.03 | 3.3 | 1.1 – 14.6 | 0.03 |
| Grade | 0.17 | 0.07 | ||||
| 1 | 1.0 | - | 1.0 | - | ||
| 2 | 2.0 | 0.34 – 39.0 | 0.7 | 0.2 – 2.7 | ||
| 3 | 5.1 | 0.85 – 100.8 | 2.0 | 0.5 – 8.7 | ||
| 4 | 2.8 × 108 | 0 – 132.6 | 1.8 × 109 | 0 – 2.2 | ||
| Day 28 Response | 0.01 | 0.001 | ||||
| CR | 1.0 | - | 1.0 | - | ||
| PR | 0.7 | 0.2 – 2.6 | 1.7 | 0.4 – 6.1 | ||
| NR | 3.7 | 1.2 – 11.4 | 5.0 | 2.0 – 13.7 | ||
| Day 28 FS ≥ 2000 pg/ml | 9.3 | 1.3 – 59.1 | 0.002 | 2.8 | 1.04 – 6.9 | 0.04 |
| Onset Ang2 ≥ 8000 pg/ml | 3.0 | 0.6 – 11.7 | 0.05 | 0.3 | 0.03 – 1.2 | 0.09 |
| Day 28 Ang2 ≥ 8000 pg/ml | 0.6 | 0.05 – 5.1 | 0.14 | 5.2 | 1.7 – 13.9 | 0.006 |
| Day 28 sEng ≥ 3000 pg/ml | 0.9 | 0.04 – 8.5 | 0.6 | 1.1 | 0.5 – 2.6 | 0.7 |
| Day 28 PlGF ≥ 20 pg/ml | 4.7 | 1.4 – 21.7 | 0.005 | 1.8 | 0.6 – 6.7 | 0.3 |
Abbreviations: Ang2=angiopoetin-2, CI=confidence interval, CR=complete response, FS=follistatin, HR=hazard ratio, NR=no response, PlGF=placental growth factor, PR=partial response.