Figure 3.
Losartan inhibits in vitro osteoclast differentiation. (A) TRAP staining of osteoclast differentiated from bone marrow monocytes using different concentration of Losartan treatment. (B) Cell counts of TRAP positive osteoclasts cultured under different concentrations of Losartan. (C) Losartan suppresses AngII induced ERK1/2 phosphorylation. (D) Losartan attenuates RANKL induced ERK1/2 phosphorylation. *p<0.05, n=4 for control and Losartan treated group.