Table 1.
Estradiol accumulation by human luteinizing granulosa cells (hLGC) treated in vitro with 3.1 nM, 3.1 pM, or 3.1 fM TCDD at various time intervals. Values are given as a percentage relative to accumulation by untreated control cells (control = 100%).
| Time Points | Control | 3.1 nM TCDD | 3.1 pM TCDD | 3.1 fM TCDD |
|---|---|---|---|---|
| 4 hour | 100% | 153.2% (16.0) | 158.2% (11.2) | 137.5% (23.9) |
| 8 hour | 100% a | 50.1% (16.6) b | 51.6% (14.5) b | 43.8% (12.3) b |
| 12 hour | 100% a | 41.2% (10.6) b | 26.7% (9.2) b | 37.3% (7.8) b |
| 24 hour | 100% a | 46.9% (15.6) b | 44.7% (15.8) b | 44.9% (18.8) b |
| 36 hour | 100% a | 104.0% (9.3) | 83.5% (8.2) | 112.8% (11.7) |
| 48 hour | 100% a | 88.2% (16.3) | 93.0% (14.4) | 84.6% (13.9) |
a,b
Letter superscripts denote significance at each time period (within a given row), based on Tukey’s post-hoc test after one-way ANOVA (P < 0.05). Values within columns sharing the same superscripts do not differ significantly from one another. Parentheses denote ± (S.E.M.) reported as a percentage. N = 8 for each treatment group.