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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Neurobiol Dis. 2015 Mar 25;78:45–55. doi: 10.1016/j.nbd.2015.03.018

Figure 4. Exercise-induced reductions in Aβ are associated with reduced BACE1.

Figure 4

(a–c) Voluntary exercise reduced both soluble and insoluble Aβ in APP/PSEN1 transgenics, in both in hippocampus and overlying cortex. (d) The reduction in Aβ in active transgenics was significantly correlated with the amount of running. Running was not associated with cortical Aβ levels. (e–g) Full-length amyloid precursor protein (APP) was measured using two different antibodies. Both immunoblots indicated that APP was significantly elevated in active APP/PSEN1 mice. (e,h–i) In contrast to APP, BACE1 was significantly reduced in active transgenics. (i) Levels of sAPPβ were unchanged in active transgenics, compared to their sedentary counterparts. *p < .05; **p < .01; ***p < .001; ****p <.0001.