Table 3.
Proteins differentially expressed between Active and Inactive (control) APP/PSEN1 mice.
| Accession number |
Protein | Gene | Mol. wt. (kDa) |
Peptides | Fold change |
p | Pathway |
|---|---|---|---|---|---|---|---|
| A3KFM7 | Chromodomain helicase DNA binding 6 | Chd6 | 305.2 | 7 | - | <.01 | Neurogenesis/neuroproliferation |
| P97477 | Aurora kinase A | Aurka | 47.1 | 4 | - | <.05 | |
| Q3UJT6 | Replication factor C (activator 1) | Rfc1 | 64.6 | 3 | - | <.05 | |
| Q64522 | Histone H2A type 2-B | Hist2h2ab | 14.0 | 3 | 0.5 | <.05 | |
| Q61488 | Desert hedgehog | Dhh | 43.5 | 2 | 0.0 | <.01 | |
| P70388 | DNA repair RAD50 | Rad50 | 153.4 | 3 | 0.0 | <.05 | |
| B1AY10 | Transcriptional repressor NF-X1 | Nfx1 | 123.7 | 4 | 0.0 | <.05 | |
| Q3TIZ0 | Tubulin α1C | Tuba1c | 249.9 | 2 | 0.9 | <.05 | Cytoskeletal regulation |
| Q3TGW0 | Actin-related 3 | Actr3 | 47.3 | 8 | 0.6 | <.05 | |
| P80316 | T-complex protein 1 subunit ε | Cct5 | 59.6 | 3 | 0.2 | <.05 | |
| E9Q7P1 | Collagen, type XXII, α1 | Col22a1 | 159.8 | 2 | 0.1 | <.05 | |
| Q5SXR6 | Clathrin, heavy chain | Cltc | 9191.8 | 91 | 0.8 | <.05 | Endocytosis |
| Q80ZI6 | E3 ubiquitin ligase LRSAM1 | Lrsam1 | 83.9 | 2 | 0.0 | <.05 | |
| Q8CBD1 | Nuclear receptor-interacting protein 1 | Nrip1 | 126.2 | 2 | - | <.05 | Protein processing |
| A2RT70 | Tenascin-R | Tnr | 1149.5 | 11 | 4.2 | <.01 | Neuritogenesis |
| Q3TJ43 | Vacuolar protein sorting-associated protein 35 | Vps35 | 91.6 | 7 | 3.2 | <.05 | |
| P08249 | Malate dehydrogenase, mitochondrial | Mdh2 | 135.6 | 6 | 1.3 | <.01 | Oxidative phosphorylation |
| P14094 | Sodium/potassium-transporting ATPase subunit β-1 | Atp1b1 | 135.2 | 10 | 0.7 | <.001 | |
| P10649 | Glutathione S-transferase μ 1 | Gstm1 | 125.9 | 6 | 0.8 | <.05 | Glutathione metabolism |
| E9Q3B9 | Monoglyceride lipase | Mgll | 35.2 | 2 | 0.0 | <.05 | Glycerolipid metabolism |
| B4DZ37 | Solute carrier family 9, isoform 10 | Slc9a10 | 51.3 | 2 | 0.0 | <.05 | Ion transport |
| A2ANU2 | Polypeptide N-acetylgalactosaminyltransferase 12 | Galnt12 | 33.1 | 2 | 3.9 | <.05 | O-Glycan biosynthesis |
| D0JYX1 | Peptidase S1 and S6, chymotrypsin/Hap | 51.5 | 2 | 3.5 | <.05 | Unknown | |
| Q6PNC0 | DmX-like protein 1 | Dmxl1 | 335.8 | 4 | - | <.05 | |
| D3Z7K0 | Ubiquitin thioesterase | Outb1 | 11.2 | 5 | 0.3 | <.05 | |
| D3Z4R5 | Uncharacterized | 42.4 | 4 | 0.0 | <.01 | ||
| F6VUT6 | Protein Gm8251 | Gm8251 | 225.8 | 3 | 0.0 | <.05 |
All proteins are listed that had significantly different main or interaction effects using 2 × 2 ANOVAs followed by Fisher's protected LSD; df = 13 for each comparison. A 0-fold change indicates that the protein was not expressed at detectable levels in the active APP/PSEN1 mice; a dash indicates that the protein was not expressed at detectable levels in the inactive APP/PSEN1 mice.