Table 3.

MNI coordinates and statistics for brain regions showing significant response for the contrast for the main effect of drug (Nicotine > Placebo, collapsed across all other conditions). Regions grouped by contiguous clusters. Z scores drawn from local maxima. Peak p was < 0.001 for all clusters.

Brain Area	Hemisphere	Brodmann Area	z score	x,y,z (mm)	Cluster Size (# of Voxels)
precentral gyrus	L	4	4.12	-54, -7, 46	457
postcentral gyrus	L	2	3.92	-48, -28, 52
precentral gyrus	L	4	3.80	-33, -19, 55
paracentral lobule	R	6	3.75	15, -25, 49	148
postcentral gyrus	R	3	3.74	9, -34, 67
medial frontal gyrus	R	6	3.66	3, -25, 55
precentral gyrus	R	4	3.42	51, -4, 43	138
middle frontal gyrus	R	6	3.28	39, -1, 49
precentral gyrus	R	9	2.86	39, 8, 37