Table 1. Gene expression analysis identifies infectious disease pathways upregulated in SS.

Analysis of gene expression data using Ingenuity revealed that pathways of viral, bacterial, and parasitic infection response were all upregulated in SS samples compared with normal controls. The above table shows the p-value for each functional pathway, the total number of molecules dysregulated in each pathway, and a selection of key molecules.

Functional Pathway	p-Value	# Molecules	Seclected Molecules
Viral Infection	5.24E-12	187	APOBEC3G,CD48, CD63, CXCR4, DEFA4, DNAJA3, DUSP1, HCP5, IRF1, ISG20, ITGB1, LCN2, MYC, MYD88, NFKBIA, OAS1, PDCD1, PGLYRP1, PSME2, RELA, S100A9, TOX, VAV1, ZAP70
Bacterial Infection	6.50E-04	43	BPI, C1QBP, CD27, CEBPB, CHIT1, CSK, DEFA4, DUSP1, E2F4, IL6ST, LY86, MAP2K3, MIF, MYD88, PILRB, REL, RELA, S100A9, SLAMF6,
Parasitic Infection	4.69E-03	18	AHNAK, ATP2B4, CXCR4, IL4R, ITGB7, MYD88, REL, SLAMF6