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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Curr Opin Immunol. 2014 Jul 31;30:63–71. doi: 10.1016/j.coi.2014.07.001

Figure 2. Genomic permissiveness in gene expression for an innate immune co-receptor gene.

Figure 2

LY96 (also known as MD2) encodes a co-receptor for LPS crucial for TLR4 activity. Variance in monocyte LY96 expression across treatments was analysed as a quantitative trait and correlated with underlying genotype. (a) rs1267688 forms a peak eQTL for LY96 expression. (b) This SNV is also most strongly associated with variance in expression over different states of induction of monocytes with LPS (2 or 24 h) or with IFNγ (24 h). A broad range is seen in expression levels for the minor allele dependent on environmental stimulus [9••] providing genomic permissivity in the population.