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. 2015 Mar 13;21(9-10):1483–1494. doi: 10.1089/ten.tea.2014.0474

FIG. 6.

FIG. 6.

The auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) thresholds of HB-EGF-treated ears compared with control. Figure shows the (a) ABR and (b) DPOAE thresholds measured at 10 weeks in ears perforated and injected with the polymer hydrogel loaded with HB-EGF at 50 μg/mL (n=13), 10 times the effective dose, compared with control ears, which were injected with the polymer hydrogel only (n=13). There were no differences between groups demonstrating a lack of ototoxicity of HB-EGF in the mouse model.