Table 3.

Hazard Ratio Estimates and 95% Confidence Intervals for Death Using Different Sizes of Subcohorts (N=13,658)

	AIDS at treatment initiation
	23 cohorts ≈500 per cohort	65 cohorts ≈200 per cohort	134 cohorts ≈100 per cohort	271 cohorts ≈50 per cohort
Fixed effects	1.99 (1.74–2.28)	2.00 (1.75–2.28)	2.00 (1.75–2.29)	2.03 (1.78–2.33)
Random effectsa	1.97 (1.72–2.25)	1.94 (1.70–2.21)	1.88 (1.65–2.14)	1.84 (1.62–2.10)
Stratified	2.00 (1.75–2.28)	2.00 (1.75–2.28)	1.99 (1.74–2.28)	2.02 (1.77–2.32)

^aModel assumes a Gaussian random effects distribution.

All analyses were adjusted for age, sex, nadir CD4 count, year of initiation, initial ART regimen, and AIDS defining condition at ART initiation.