Table 4.
Stepwise linear regression of select neuropsychological outcomes of adolescents with tetralogy of Fallot without genetic anomalies (n=68), adjusting for concurrent family social status
| Variable | Number of Complications at First Surgery (vs. None)
|
Other Covariates | |
|---|---|---|---|
| One | Two or More | ||
| β ± SE (P value) | |||
| Wechsler Intelligence Scale | |||
| Verbal Comprehension | −6.9 ± 5.2 (0.19) | −17.0 ± 5.9 (0.006) | - |
| Perceptual Reasoning | - | - | One surgical complication (vs. None): −14.8 ± 5.3 (0.007) Two or more surgical complications (vs. None): −24.0 ± 4.8 (<0.001) Three or more open surgeries (vs. < 3): 17.1 ± 5.5 (0.003) |
| Working Memory | - | - | One surgical complication (vs. None): −9.9 ± 5.7 (0.09) Two or more surgical complications (vs. None): −15.6 ± 5.0 (0.003) |
| Processing Speed | - | - | - |
| Full-Scale IQ | −9.9 ± 5.4 (0.07) | −20.1 ± 6.1 (0.002) | - |
| Wechsler Individual Achievement Test | |||
| Reading Composite | - | - | Seizures (vs. None): −18.4 ± 6.9 (0.01) |
| Mathematics Composite | −10.8 ± 6.0 (0.07) | −29.1 ± 6.8 (<0.001) | - |
| General Memory Index | - | - | Male: 13.7 ± 4.8 (0.006) One surgical complication (vs. None): −7.2 ± 6.3 (0.26) Two or more surgical complications (vs. None): −16.0 ± 5.3 (0.004) Gestational age (wk): 2.0 ± 0.9 (0.04) |
| Executive Function Summary Score | −0.8 ± 0.7 (0.29) | −2.5 ± 0.8 (0.003) | - |
| Behavior Rating Inventory of Executive Function | |||
| Parent | - | - | Non-Hispanic Caucasian: −10.5 ± 4.2 (0.02) |
| Teacher | - | - | - |
| Visual-Spatial Summary Score | −13.3 ± 4.8 (0.008) | −25.0 ± 5.5 (<0.001) | |
| Parent Conner’s ADHD Index T Score | - | - | Seizures (vs. None): 25.7 ± 6.1 (<0.001) Birth weight (kg): −3.8 ± 1.9 (0.0498) |
| Reading the Mind in the Eyes | - | - | Gestational age (wk): 0.7 ± 0.3 (0.01) Seizures (vs. None): −6.6 ± 2.7 (0.02) Age at developmental testing: 1.4 ± 0.6 (0.03) One or two catheterizations (vs. None): −3.6 ± 1.7 (0.04) Three or more catheterizations (vs. None): 0.8 ± 1.8 (0.66) |
| Autism Spectrum Quotient | - | - | DHCA duration: 0.08 ± 0.03 (0.01) |
All characteristics from Table 1 were considered for inclusion in the regression models except NYHA classification and any neurological event. Coefficients for intercepts and family social status are not reported.