Cranial traits exhibited by newborn tuft mice. (A) Anterior cephalocele. (B) Large cephalocele and midfacial cleft. (C, D) Severe midfacial cleft with an anterior cephaplocele or epidermal lesion (arrow). (E-H) Superior views of skulls indicating cranial bone (N, nasal; F, frontal; P, parietal) and suture character from a normal appearing newborn (E) compared to it’s sibling with a cyst (F) that emanated through a broadened interfrontal suture (IFS, arrow) between the frontal bones (asterisk). (G) Newborn with a bifid nose and large cephalocele similar in size to pup shown in (B), lacking frontal bones (asterisk). (H) Skull from pup with a midfacial cleft and subtle surface lesion or cyst similar to pup shown in (D), also had a broadened IFS (asterisk).