Figure 2.

S20 has potent anti-influenza activity: compound S20 and its antiviral activity against influenza A virus. (a) Chemical structure of compound S20 and its molecular weight (MW). (b) A549 cells were infected with influenza A/WSN/33 virus (MOI = 0.01) in the presence of increasing concentrations of compound S20. Viral titers were determined at 24 h postinfection (left-hand scale, solid line) and the IC₅₀ and IC₉₀ calculated. Cell viability was determined independently for a 24 h incubation period (right-hand scale, dashed line), and the CC₅₀ and CC₁₀ were calculated. Means of three replicates ± SD are shown.