Structure of prefusion GP bound to antibodies.
(A) Overlay of complexes for GP (spacefill) bound to KZ52 Fab (yellow,
which targets GPEBOV, PDB ID 3CSY, ref (7)) and 16F6 Fab (cyan, which targets GPSUDV, PDB ID 3S88, ref (6)). GP1 is
colored green, and GP2 is colored light gray. There is partial overlap
in the structural epitopes. (B) Surface representation of GPSUDV with residues that correspond to 16F6, KZ52, or shared structural
epitopes color-coded according to the scheme shown in the inset. The
two structural epitopes overlap at 10 residues, labeled on the surface
representation.