Fig. 5.
Requirement for type II Fc receptors for IVIG/F241A-mediated protection in EAE. EAE was induced by immunization with MOG35–55 peptide. Mice received i.v. injections on days 5, 10, 15, and 20 postinduction. Clinical scores of disease are displayed. (A) C57BL/6 wild-type and SIGN-R1−/− mice were treated with IVIG (1 g/kg) or PBS. (B) SIGN-R1−/− mice were given IVIG (1 g/kg) as mentioned above or IL-33 (0.5 µg) i.p. every 2 d starting on day 5 post EAE induction. (C) SIGN-R1−/− and SIGN-R1−/− hDC-SIGN+ mice were treated with PBS or IVIG (1 g/kg). (D) SIGN-R1−/− hDC-SIGN+ mice received nonsialylated F241A (asialo-F241A) (0.033 g/kg) or PBS control. Means ± SEM are plotted; *P < 0.05; **P < 0.01; ***P < 0.001 determined by Tukey’s post hoc test.