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. 2015 Mar 12;34(9):1231–1243. doi: 10.15252/embj.201490578

Figure 6. Genetic disruption of FGF22 signaling impedes functional recovery following spinal cord injury.

Figure 6

  1. Image of a spinal cord injured mouse performing the irregular ladder rung test that assesses recovery of CST function. Scale bar equals 1 cm.
  2. Quantification of the functional recovery in the ladder rung test (regular walk, left panels; irregular walk, right panels) in FGF22-deficient (top panels, red bars), and hindlimb motor cortex FGFR1/FGFR2 double-deficient (bottom panels, blue bars) mice and the respective FGF22- and FGFR-competent control mice (white bars) before (‘Pre’) and 2 (‘2 wks’) and 3 (‘3 wks’) weeks after a spinal cord injury (n = 7–10 animals per group). *P < 0.05, **P < 0.01 (repeated-measure ANOVA followed by Bonferroni tests).
  3. Image of a spinal cord injured mouse walking on the catwalk that assesses locomotor recovery. Illumination of the paws from below allows to determine the paw angle body axis by relating the axis of the paw (line shown magnified in the right panel) to the axis of the body (line shown in left panel).
  4. Quantification of the paw angle body axis of the hindpaws in FGF22-deficient (top panel, red bars) and hindlimb motor cortex FGFR1/FGFR2 double-deficient (bottom panel, blue bars) mice and respective FGF22- and FGFR-competent control mice (white bars) before (‘Pre’) and 2 (‘2 wks’) and 3 (‘3 wks’) weeks after a spinal cord injury. Between 13 and 40 steps were analyzed per group and timepoint (n = 10–15 animals per group). **P < 0.01, ***P < 0.001 (two-way ANOVA followed by Bonferroni tests).