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. Author manuscript; available in PMC: 2015 May 11.
Published in final edited form as: Ann Neurol. 2014 Apr 28;75(5):659–669. doi: 10.1002/ana.24144

Figure 3. Area of HCS in a PML patient with idiopathic CD4+ lymphocytopenia.

Figure 3

Horizontal lines separate cortex (above) from white matter (below) (A) Myelin stain demonstrates nearly complete demyelination with rare relatively preserved areas (LFB-H&E, 100x). (B) CD68 staining shows perivascular and interstitial macrophages and activated microglia present in white matter as well as deep cortex (CD68, 100x) GFAP staining at low and high magnifications (C and D) highlights prominent astrogliosis in white matter and JCV focal leukocortical encephalitis in deeper cortical layers (C-100x, D-400x).