Table 3.
Reference Set DDI and coverage in NDF-RT and DrugBank
| Grp # | DDI group description | # pairs | NDF-RT matches | DrugBank matches | Object members | Precipitant members |
|---|---|---|---|---|---|---|
| 3 | Amphetamine and derivatives – MAO inhibitors | 60 | 30 (50%) | 30 (50%) | Dexmethylphenidate, Dextroamphetamine, Methylphenidate, Lisdexamfetamine, Phendimetrazine, Pseudoephedrine, Amphetamine, Benzphetamine, Diethylproprion, Phentermine, Atomoxetine, Methamphetamine | Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline |
| 4 | Atazanavir – Proton pump inhibitors (PPIs) | 5 | 5 (100%) | 5 (100%) | Atazanavir | Omeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Esmoprazole |
| 8 | Fluoxetine - MOA inhibitors | 55 | 39 (71%) | 43 (78%) | Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Fluvoxamine, Duloxetine, Nefazodone, Desvenlafaxine, Milnacipran, Venlafaxine | Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline |
| 11 | Irinotecan – Ketoconazole | 23 | 1 (4%) | 5 (22%) | Irinotecan | Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Ketoconazole, Itraconazole, Fluconazole, Voriconazole, Nefazodone, Aprepitant, Cimetidine |
| 16 | Narcotic analgesics – MAO inhibitors | 30 | 25 (83%) | 15 (50%) | Meperidine, Methadone, Tapentadol, Fentanyl, Tramadol, Dextromethorphan | Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline |
| 22 | Ramelteon-fluvoxamine | 4 | 0 (0%) | 2 (50%) | Ramelteon | Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin |
| 23 | Rifampin – ritonavir | 60 | 41 (68%) | 25 (42%) | Bosentan, Rifapentine, Carbamazepine, Rifabutin, Rifampin, St. John’s wort | Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir |
| 25 | HMG Co-A reductase inhibitors – protease inhibitors | 40 | 38 (95%) | 33 (83%) | Simvastatin, Lovastatin | Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline |
| 27 | Telithromycin – ergot alkaloids and derivatives | 60 | 13 (22%) | 35 (58%) | Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Ketoconazole, Itraconazole, Voriconazole | Ergotamine, Methylergonovine, Dihydroergotamine, Ergonovine |
| 28 | Tizanidine – ciprofloxacin | 7 | 6 (86%) | 6 (86%) | Tizanidine | Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin, Mexiletine, Propafenone, Zileuton |
| 30 | Tranylcypromine – procarbazine | 1 | 1 (100%) | 1 (100%) | Tranylcypromine | Procarbazine |
| 31 | Triptans – MAO inhibitors | 15 | 8 (53%) | 11 (73%) | Sumatriptan, Zolmitriptan, Rizatriptan | Tranylcypromine, Phenelzine, Isocarboxazid, Moclobamide, Methylene blue |
| TOTAL | 207 (58%) | 211 (59%) |