Table 5.

Top ATC Class Pairs

ATC Class Pair	total DDIs	NDF-RT only	DrugBank only	both	Jaccard
Protease inhibitors - Protein kinase inhibitors	103	72	10	21	0.20
Benzodiazepine derivatives - Protease inhibitors	88	5	52	28	0.32
Adrenergic and dopaminergic agents - Non-selective monoamine reuptake inhibitors	78	0	78	0	0
Antibiotics - Other quaternary ammonium compounds	71	35	8	28	0.39
Penicillins with extended spectrum - Tetracyclines	63	0	58	5	0.08
Protein kinase inhibitors - Triazole derivatives	60	32	10	18	0.30
Beta blocking agents, non-selective - Sulfonamides, urea derivatives	56	10	14	32	0.57
Macrolides - Protein kinase inhibitors	56	27	14	15	0.27